It starts with an email notification.

An interesting opportunity. Care to hop on a conference call to discuss?

The three University of Nebraska at Omaha students are intrigued.

 On the phone, the pitch goes like this:

Would you like to build a groundbreaking mobile application with considerable value as a public health tool? It’ll involve collaborating with two teams.

The first is the University of Nebraska Medical Center’s Global Center for Health Security, which is rapidly working to quell an unprecedented global health crisis and is also home to the nation’s only federal quarantine unit. The other is Apple Inc.

With the COVID-19 pandemic having recently arrived in Nebraska, spring break has come early.

No need to juggle coursework.

The students quickly agree.

Work begins immediately. Prototyping and wireframing and coding. Analysis and dialogue and refinement. Daily meetings stretch into the pre-dawn hours as each team navigates hunger — the UNMC team subsisted on takeout curry — exhaustion and multiple time zones.

As news segments turn some of their peers infamous during imprudent trips to warmer regions, Keegan Brown, Grayson Stanton and Carly Cameron spend their spring break tucked away in a design studio, maintaining 6 feet of separation and working in conjunction with experts in the fields of medicine and technology.

Less than three weeks later, 1-Check COVID was available in the Apple App Store and was downloaded more than 10,000 times in the first 10 days. The app is now also available on Google Play for Android phone users.

1-Check COVID is a risk-assessment tool that asks the user a series of questions ranging from biographical to geographical before inquiring about symptoms. All are computed in an effort to assess the likelihood of someone having contracted COVID-19. Once the questions are completed, users learn their risk levels: low, urgent or emergent. From there, they are guided toward subsequent steps, whether to continue to monitor their symptoms or contact the public health department. If users agree, they can share their risk profiles with health care professionals, employers and family members, among others.

“This will hopefully be lifesaving,” UNO and UNMC Chancellor Jeffrey P. Gold, M.D., said in a news release, which names the three Scott Scholars, who are all Nebraska natives, computer science majors and underclassmen. Cameron, the oldest of the trio, was 2 years old when the SARS outbreak occurred. She doesn’t remember it.

In a time of crisis, both UNMC and Apple have bet on youth. And youth has delivered.

“What these students did is nothing short of extraordinary,” said Harnoor Singh, director of student development for the Walter Scott, Jr. Scholarship Program (Scott Scholars), which was launched in 1997, thanks to the generous support of the Suzanne & Walter Scott Foundation. The program challenges high-achieving engineering and information science and technology students to develop their technical, creative and leadership skills.

“These are the students we’ve been waiting for,” Singh added.

In 2019, researchers and the media began sounding alarm bells about a “loneliness epidemic” — a rise in people reporting feelings of isolation that could become a health crisis, leading to increases in heart disease or even shorter life spans.

And that was before COVID-19. Before the world shut itself indoors and government leaders mandated, and pleaded, for everyone to stay at least 6 feet apart.

Isolation and social distancing are terms the world is all too familiar with now.

“I have, for years, been trying to come up with ways to make people more aware,” said Todd Richardson, Ph.D., an associate professor in the University of Nebraska at Omaha Goodrich Scholarship Program who is researching loneliness. “And then this comes around and does it for me.”

What researchers like Richardson have warned of — fraying social connections and the ways people arrange their lives to perpetuate isolation — rocketed to the world’s collective consciousness as COVID-19 spread rapidly across the globe. As cities, states and countries shut down, everyone felt the pain of isolation. People kept friends and family members at bay. They missed play dates, barbecues, birthday parties and graduation ceremonies. They missed the rush and roar of live music, the shared excitement of home runs and 3-pointers. They wondered if the “sea of red” would ever wash over Memorial Stadium in quite the same way.

And everyone felt those things, together.

“It’s ironic that the experience of loneliness unites us, but I think it can in this moment,” said Richardson. “We’re all under threat from something that doesn’t discriminate between human beings. This is an extra-human threat. So we can bond as humans and realize we’re working together in order to resist this. And I think there’s something really, really beautiful in that.”

But there’s a flip side to that potential beauty. The longer people stay apart, the harder it becomes to return to one another.

“There is a period where you acknowledge the loss in your life, and you lament it, and you try and fill it in whatever way you can,” Richardson said. “But the longer you’re away from other people, the less trust you have for other people, so the harder it gets to break out and to reach out. And at that point, loneliness starts feeding in on itself. It becomes a self-perpetuating kind of cycle.”

Richardson said social interaction influences people in ways they’re not even aware of. Seeing another person express emotions, such as joy and pain, sparks a mirror response in the brain.

“The mere fact of making eye contact with them, or being in the same physical space as them, connects us to them in important ways,” he said. “It makes us acknowledge them as people, as fellow humans, as entities worthy of respect and autonomy.”

Fundamentally, Richardson said, it teaches people empathy.

“The longer we retreat from one another,” he said, “the longer we don’t share that physical space, the less empathetic we get, and the less we care about other people.”

There is also risk in social interaction, and humans are inherently risk-averse, Richardson said. People may want to avoid not just the risk of disease, but the risk of shame, embarrassment or rejection that comes with putting themselves out there in the world. The longer people stay protected, the more comfortable they may become.

“I think that when this abates, we’re going to have a lot of work ahead of us reacclimating and coming to terms with the fact that we need one another,” he said, “and that is worth the risks that we take.”

Jacob Robinson’s dream of being a major league pitcher didn’t pan out. Something better did: He teamed up with fellow University of Nebraska at Omaha biology graduate student Nik Stevenson and together, this past year, made a breakthrough in cancer research — one that could make a major impact in the lives of people around the world who are fighting a rare type of lymphoma. And along the way, the two say, they discovered passions that could make a major impact in their own lives and careers.

They credit the supportive culture at UNO.

Says Robinson: “People here, especially the science faculty, are so willing to help students that I really felt like my education here was great. Because I was willing to put in the effort, people were always willing to provide opportunities for me to go as far as I wanted to go.”

Says Stevenson: “You can fail 10, 20, 100 times, and the faculty here will help you succeed. It’s an environment where you feel confident that even if you fail, you’re ultimately going to succeed, and that’s pretty important to help you flourish.”

The cancer they’re studying is called splenic marginal zone lymphoma, or SMZL. It’s a type of white blood cell cancer that hasn’t been studied a lot because it’s so rare. SMZL cases have an overall survival prognosis after diagnosis of eight to 11 years, so it’s a rather slow-progressing cancer.

But anywhere from 10% to 15% of those cases progress to a much more aggressive form in which the overall survival prognosis drops to three to five years. Their research has shown promise in predicting how aggressive a person’s cancer will be based on specific genetic markers, a breakthrough that could lead to a way to more easily diagnose this cancer.

Stevenson did the “wet bench” side of their research — the hands-on work with the cancer cells themselves. Robinson did the big-data side, studying the genetic profiles of patients with SMZL and looking for patterns for this specific blood cancer vs. other similar lymphomas.

“It’s not a terribly lethal (cancer), unless it transforms,” Robinson says. “What my research did is, I found a grouping of markers that is pretty highly predictive for the basis of diagnosis for this SMZL patient.

“Instead of having to go through a bunch of different tests, ideally you would be able to just have this panel of genetic markers from a biopsy, and you’d say yes or no, this is the lymphoma that they’re afflicted with.”

If patients have the slow-growing type, they wouldn’t have their lives disrupted as much with frequent biopsies, along with the waiting around for results, which can be scary. It also would provide more accurate diagnosis and information on the outcome of the disease’s progression.

Says Stevenson: “It would allow them to pretty much have a better quality of life for the time being.”